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Randi et al. 2023

Neural signal propagation atlas of Caenorhabditis elegans

Randi, F., Sharma, A.K., Dvali, S., Leifer, M.
Nature 623, 406–414 (2023)

Datasets: WormNeuroAtlas - Anatomical - WormNeuroAtlas - Functional

Summary

  • Aims to understand the relationship between structure and function of the connectome by measuring signal propagation of C.elegans using direct optogenetic activation and simultaneous whole-brain calcium imaging
  • the functional atlas is built upon:
    • anatomical datasets (White et al. 1986; Witvliet et al. 2021)
    • genome (Wormbase.org)
    • single-cell transcriptome (Taylor et al. 2021)
    • neuropeptide/GPCR deorphanization (Beets et al. 2023)
    • monoaminergic connectome (Bentley et al. 2016)
    • neuropeptidergic connectome (Ripoll-Sanchez et al. 2023)