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Taylor et al. 2021

Molecular topography of an entire nervous system

Seth R. Taylor, Gabriel Santpere, Alexis Weinreb, Marc Hammarlund, Oliver Hobert, David M. Miller

Cell, Volume 184, Issue 16, 2021, Pages 4329-4347.e23
Published: July 07, 2021:

Summary

  • Gene expression profiles of all 118 neuron classes in the C.elegans hermaphrodite
  • Each neuron type expresses a distinct code of neuropeptide genes and receptors
  • Expression profiles enable discovery of cell-type-specific cis-regulatory sequences
  • Cell adhesion molecules correlate with neuron-specific connectivity.
  • This data was used by Ripoll-Sanchez et al. (2023) to generate the neuropeptidergic connectome.